v7v2: 人類到底能不能長壽?科學家這麼說

人類到底能不能長壽?科學家這麼說


25 Dec 2021 at 02:27am
人類到底能不能長壽?科學家這麼說

關鍵詞:亞精胺,衰老,自噬,健康期

越來越多研究表明,天然多胺亞精胺的外源性補充可以延長包括酵母、線蟲、果蠅和小鼠在內的模式動物的壽命。同樣地,流行病學研究證據顯示,通過增加亞精胺的攝入,也可以降低人類的總體死亡率,同時降低心血管和癌症的發病率。

奧地利格拉茨大學分子生物科學研究所曾在《Aging》雜誌中探討亞精胺效應的可能機制。在過去十年中,他們的研究小組發現,將亞精胺添加到酵母、線蟲等培養基中就足以在多個層面延長生物的壽命並改善健康跨度;此外,兩項基於人群的前瞻性研究首次報告說,營養性亞精胺的攝取也支持延長人類健康期。





注:亞精胺可以通過對細胞健康的整體影響來抵消衰老的一般影響( A ),或者可以對心血管功能、抗癌免疫監視或神經變性產生特定影響,從而降低主要年齡相關疾病的發病率(B)

事實上,亞精胺延緩年齡相關疾病和死亡的分子和細胞機制已在一定程度上得到闡明。亞精胺可以作為腺病毒早期區域1A相關蛋白p300乙酰轉移酶活性的抑製劑,最著名的是EP300。EP300是自噬的內源性抑製劑,而亞精胺對EP300的抑制會刺激自噬。另外在小鼠中,心肌或癌細胞中自噬基因的缺失分別降低了亞精胺對心血管疾病和癌症的有益作用,這一事實表明,自噬的遺傳抑制會消除亞精胺對酵母、蠕蟲和果蠅的長壽作用。可以說,自噬是亞精胺抗衰延壽作用的關鍵機制。

除上述研究結果外,亞精胺已被歸類為“熱量限制模擬物”,能誘導與熱量限制類似的生化變化,因此具有廣泛的健康促進作用。雖然亞精胺對人類健康作用的機制尚未完全闡明,但根據目前的研究來看,亞精胺是減緩衰老、對健康產生全身影響的重要物質。日本藤素評價日本藤素台灣藥局日本藤素美國黑金壯陽藥春藥日本騰素日本藤素哪裡買日本藤素真假辨別日本藤素副作用日本藤素效果正品日本藤素日本藤素心得日本藤素案例日本藤素價格

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